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　　Title:ky平台官网 Digital Microfluidic Biochips: From Manipulating Droplets toQuantitative Gene-Expression Analysis

　　Speaker: Prof.ky娱乐网站 Krishnendu Chakrabarty, Duke University

　　Time: 2017年9月27日上午11:00

　　Location: 北航新主楼F708

Abstract

Advances inmicrofluidics have led to the emergence of biochips for automating laboratoryprocedures in molecular biology.ky网站平台 These devices enable the precise control ofnanoliter volumes of biochemical samples and reagents. As a result, newbiomedical applications and markets (e.g., high-throughout DNA sequencing,portable and point-of-care clinical diagnostics, and protein crystallizationfor drug discovery) are opening up for integrated circuits and miniaturizedelectronic systems.

　　Thislecture will first introduce digital microfludic biochips based onelectrowetting-on-dielectric, describe market drivers such as DNA sequencingand clinical diagnostics, and highlight recent commercialization successstories. The audience will next learn about design automation and dynamicreconfiguration aspects of microfluidic biochips. Synthesis tools will bedescribed to map assay protocols from the lab bench to a droplet-basedmicrofluidic platform and generate an optimized schedule of bioassayoperations, the binding of assay operations to functional units, and the layoutand droplet-flow paths for the biochip. The role of the digital microfluidicplatform as a “programmable and reconfigurable processor” for biochemicalapplications will be highlighted. The speaker will also describe sensor-drivenon-chip error recovery through cyberphysical system integration.

Finally,the speaker will highlight recent advances in utilizing cyberphysicalintegration for quantitative gene-expression analysis and single-cell analysis.This framework is an attempt to cross the formidable barrier that separatesbiochip engineering from mainstream microbiology research. Today’smicrofluidics design-automation (“synthesis”) techniques do a lot more thanon-chip droplet manipulation; they incorporate the myriad complexities ofbiomolecular protocols and they are therefore expected to make a positiveimpact on biochemistry/microbiology research.

SpeakerBiography

KrishnenduChakrabarty received the B. Tech. degree from the Indian Institute ofTechnology, Kharagpur, in 1990, and the M.S.E. and Ph.D. degrees from theUniversity of Michigan, Ann Arbor, in 1992 and 1995, respectively. He wasAssistant Professor of Electrical and Computer Engineering at Boston Universityduring 1995-1998. He is now the William H. Younger Distinguished Professor andChair in the Department of Electrical and Computer Engineering and Professor ofComputer Science at Duke University. Prof. Chakrabarty is a recipient of theNational Science Foundation CAREER award (1999), the Office of Naval ResearchYoung Investigator award (2001), the Humboldt Research Award (2013), the IEEETransactions on CAD Donald O. Pederson Best Paper Award (2015), the ACMTransactions on Design Automation of Electronic Systems Best Paper Award (2017)and over a dozen best paper awards at major IEEE conferences. He is also arecipient of the IEEE Computer Society Technical Achievement Award (2015) andthe IEEE Circuits and Systems Society Charles A. Desoer Technical AchievementAward (2017).

　　Prof. Chakrabarty’s current research projectsinclude: design-for-testability of integrated circuits and systems; microfluidicbiochips; data analytics for fault diagnosis, failure prediction, and hardwaresecurity. He is a Fellow of ACM, a Fellow of IEEE, and a Golden Core Member ofthe IEEE Computer Society. Prof. Chakrabarty served as the Editor-in-Chief of IEEE Design & Test of Computersduring 2010-2012 and ACM Journal onEmerging Technologies in Computing Systems during 2010-2015. Currently heserves as the Editor-in-Chief of IEEETransactions on VLSI Systems.

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